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The Institute of Metals, Chinese Academy of Scienc - Posted By Kwok (kwok) on 8th Dec 22 at 1:34am
Original title: Important progress has been made in the research of copper-containing antibacterial titanium alloys by the Institute of Metals of the Chinese Academy of Sciences Biomedical metal materials (titanium alloy, stainless steel, cobalt-based alloy, etc.) Have been widely used in orthopedics, dentistry, luminal stents and other clinical fields because of their excellent comprehensive mechanical properties, processability and reliability of clinical use, such as cardiovascular stents, fracture fixation devices, artificial joints, spinal correction, dental implants and so on. With China's gradual aging society, cardiovascular and cerebrovascular diseases, osteoporotic fractures,Titanium welding pipe, tooth loss and other problems are increasing, and metal medical devices for the repair and replacement of human tissues and organs play an irreplaceable role. However, the problem of bacterial infection caused by medical devices has become a long-standing pain point in clinic. Aiming at the important clinical problems of infection caused by metal implants, Yang Ke and Ren Ling, Institute of Metals, Chinese Academy of Sciences,ti6al4v eli, put forward the innovative idea of developing antibacterial medical metals. Recently, important progress has been made in the application of antibacterial Ti-Cu dental implants and antibacterial Ti6Al4V-Cu fracture fixation devices developed by the team in the fields of stomatology and orthopaedics. Fig. 1 The mechanism of Ti-Cu alloy inhibiting peri-implantitis. Aiming at the oral clinical problems such as frequent peri-implant inflammation, the team cooperated with the Chinese University of Hong Kong, the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and the Department of Stomatology of the General Hospital of the Northern War Zone of the Chinese People's Liberation Army to construct an animal model through a high-sugar diet and the use of Beagle dogs'oral bacteria, which was sold on the market with high cost performance and large consumption. The anti-infection mechanism of Ti-Cu implant and its effect on oral microbiome were studied from the perspective of oral microecological balance by using metagenomics technology for the first time. The results showed that compared with Denten implant, Ti-Cu implant could maintain the flora balance between anaerobic bacteria and aerobic bacteria around it, promote the normal microenvironment of oral aerobic respiration and metabolism, avoid the microenvironment tending to anaerobic and acidification, inhibit the reproduction of anaerobic acid-producing bacteria, and then inhibit the occurrence of peri-implantitis (Fig. 1). This result breaks the traditional concept that "antibacterial materials kill bacteria in animals". Relevant research results were recently published online in Bioactive Materials. Liu Hui, ti6al4v ,titanium filler rod, a doctoral student of the Institute of Metals in 2019, is the first author, Tang Yulong, deputy chief physician of the Department of Stomatology, General Hospital of the Northern War Zone of the Chinese People's Liberation Army, is the co-first author, Ren Ling, a project researcher of the Institute of Metals, Qinling Professor of the Chinese University of Hong Kong, and Yang Ke, a researcher of the Metal Institute, are the corresponding authors. Methicillin-resistant Staphylococcus aureus (MRSA) is a common and highly toxic bacteria in orthopedic clinic, which is very easy to cause bacterial infection of orthopedic implants. MRSA has been classified by the World Health Organization as a pathogen that poses a significant threat to public health. Expand the full text Fig. 2 Anti-infection study of Ti6Al4V-Cu spicule In view of the above orthopedic clinical problems, the team cooperated with Dai Rong, academician of the Department of Orthopaedics, Ninth People's Hospital Affiliated to Shanghai Jiaotong University, to study the anti-MRSA infection effect of antibacterial Ti6Al4V-Cu bone needles in animals. The results showed that Ti6Al4V-Cu bone needles could effectively inhibit the occurrence of MRSA infection in bone, while clinical infection phenomena such as severe bone tissue swelling, inflammatory tissue and a large number of bacteria adhered to the surface occurred after Ti6Al4V bone needles were implanted (Fig. 2). The study of anti-infection mechanism showed that Ti6Al4V-Cu inhibited the infection of implants by inhibiting the formation of bacterial biofilm and the expression of adhesion-related genes. The findings were published in the journal Acta Biomaterialia. Dr. Zhuang Yifu of Shanghai Jiaotong University is the first author, Ren Ling Project Researcher of Metal Research Institute is the co-first author, Yang Ke Researcher of Metal Research Institute and Dai Rong Academician of Orthopaedics Department of Ninth People's Hospital Affiliated to Shanghai Jiaotong University are the corresponding authors. The Ti-Cu and Ti6Al4V-Cu antibacterial titanium alloys developed by the team not only play an anti-infective role, but also have excellent biological safety.
At present, Ti-Cu and Ti6Al4V-Cu have completed all biocompatibility tests in Sichuan Medical Device Biomaterials and Products Inspection Center, including cytotoxicity, maximum sensitization dose, irritation, acute systemic toxicity, bone implantation, Ames, chromosome aberration, TK gene mutation, etc. The materials fully meet the relevant requirements of national medical titanium alloy standards. The above research was supported by the National Key Research and Development Program, the Key and General Program of the National Natural Science Foundation of China,titanium exhaust tubing, the Key International Cooperation Program of the Chinese Academy of Sciences, and the "Xingliao Talent Plan" of Liaoning Province. Source: Institute of Metals, Chinese Academy of Sciences Link to the paper Https:// back to Sohu to see more Responsible Editor:.